Stimulated Muscle Protien Synthesis Therapy

Stimulated Muscle Protien Synthesis Therapy



resistance exercise is a potent stimulus for an increase in muscle protein synthesis and subsequent muscular hypertrophy. After an acute bout of high-intensity resistance exercise, muscle protein synthesis increases significantly within 1–2 h and remains elevated for up to 48 h (34, 36, 37). The mammalian target of rapamycin (mTOR) signaling pathway plays a significant role in stimulating translation initiation and muscle protein synthesis (50). Recent studies have shown that the activation of mTOR signaling pathway is gradually activated during the recovery phase of resistance exercise (5, 9, 20). In fact, mTOR signaling to its downstream effector, ribosomal S6 kinase 1 (S6K1), is involved in the regulation of mRNA translation initiation and appears to be a critical regulator of exercise-induced muscle protein synthesis and training-induced hypertrophy (3, 4, 39). More recently, we have shown that following an acute bout of resistance exercise, the mTOR signaling pathway is activated in association with an increase in protein synthesis in human skeletal muscle (9). Furthermore, the phosphorylation of Akt/protein kinase B (PKB) increased and the phosphorylation of eukaryotic translation elongation factor 2 (eEF2) decreased during postexercise recovery (9). Akt activation promotes mTOR phosphorylation and signaling (50). Additionally, mTOR signaling to S6K1 inhibits eEF2 kinase, which reduces eEF2 phosphorylation and thus promotes translation elongation.




Study on Stimulated Muscle Protien Synthesis Therapy
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