In January 2016 a study the demonstrated that PEMF - Pulsed Electro-Magnetic Field Therapy proved to be an effective treatment for those individuals suffering Rheumatoid Arthritis. Club Recharge offers PEMF treatments for those individual suffering.
Targeting Mesenchymal Stromal Cells/Pericytes (MSCs) With Pulsed Electromagnetic Field (PEMF) Has the Potential to Treat Rheumatoid Arthritis
Under normal physiological conditions, MSCs in the joint are believed to contribute to the maintenance and repair of joint tissues. In RA, however, the repair function of MSCs appears to be repressed by the inflammatory milieu. In addition to being passive targets, MSCs could interact with the immune system and play an active role in the perpetuation of arthritis and progression of joint damage (54). Achieving homeostasis in the face of acute inflammatory/immune challenges in the human body involves maintaining a balance of highly complex biochemical and cellular interactions. When this delicate balance is upset, acute inflammatory and immune responses designed to quickly eliminate a transient threat become chronic, and inflammatory/autoimmune disease sets in. RA is a paradigmatic autoimmune disease, and current RA therapies target inflammatory molecules involved in autoimmune activation. Despite the therapeutic improvements in RA, there are still a substantial number of patients who respond only transiently to these approaches, and others who do not respond at all. As such, there is an urgent unmet need to identify complementary and innovative therapies for the treatment of RA. PEMF is emerging as a novel and highly promising means of treating chronic inflammation and aberrant immunity that exists in diseases such as RA. It can be used to target aberrant MSCs to potentially bring the inflammatory milieu back to homeostasis. Cellular electrical properties such as membrane surface charge and membrane potential can be readily influenced by PEMF (151–153), which can affect oscillatory frequencies of the myriad of enzymes present within the cells. PEMF can also influence cell membranes, nucleic acids, and bioelectrical phenomena generated by coherent groups of cells that are essential to cell-to-cell communication processes (154, 155). PEMF appears to exert its effects on cellular function and differentiation by altering the spatial and temporal patterns of intracellular calcium (Ca2+) concentration (10) and restoring levels/activity of potassium (K+) channels (17, 156, 157). By restoring normal Ca2+ ion flux and Na+/K+ balance, the cell can begin the process of down-regulating inflammatory cytokines, heat-shock proteins, and proangiogenic molecules such as VEGF (157), making it possible for the body to commence rebuilding healthy cartilage. Using PEMF to modulate inflammation and immune function is relatively safe in contrast to the broad immunosuppression currently in clinical favor (39, 158). An alternative to immunosuppression–healthy immunomodulation and tissue repair–can be achieved by targeting MSCs with PEMF. While traditional approaches target individual molecules or signaling pathways, PEMF works on all cellular/organismal systems in a holistic and integrative manner by potentially bringing the transmission and flow of information (signal transduction) back to a state of homeostasis via coherence of sinusoidal pulses (159). There are other potential advantages of PEMF including low-cost, easy-to-use at-home, without adverse effects. While cell therapies or biologics suffer from the possibility of loss of efficacy over time (87), preliminary clinical studies with PEMF have shown no loss of efficacy even after exposure to the field has ended (160). Another key unsolved problem in the treatment/management of RA is determining the optimal duration of therapy, and the lack of data to inform clinicians whether drugs should be suspended once remission of the disease is obtained (87). PEMF has the advantage of use without concerns regarding global immunosuppression until the desired clinical outcome is obtained (87). Since MSCs are ubiquitous, targeting their regenerative, and anti-inflammatory capacities would be an optimal combination of exogenous (PEMF), and endogenous (MSC) therapies. Clinical applications include whole-body mats for systemic approach (161), and hand-held devices for localized therapy (149). For localized applications, direct capacitive coupling mechanisms such as electrodes adhere to the site of inflammation/tissue degeneration. For non-direct capacitive/inductive coupling, mats can be used for full body applications. Current research shows optimal frequency <75 Hz, with optimal intensity (field strength) <5 mT, and optimal time courses ranging between 15 and 90 min, with longer duration most effective for severe symptoms.
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